High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
Top Cited Papers
- 9 April 2006
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 38 (5), 515-517
- https://doi.org/10.1038/ng1769
Abstract
Here we show that in substantia nigra neurons from both aged controls and individuals with Parkinson disease, there is a high level of deleted mitochondrial DNA (mtDNA) (controls, 43.3% ± 9.3%; individuals with Parkinson disease, 52.3% ± 9.3%). These mtDNA mutations are somatic, with different clonally expanded deletions in individual cells, and high levels of these mutations are associated with respiratory chain deficiency. Our studies suggest that somatic mtDNA deletions are important in the selective neuronal loss observed in brain aging and in Parkinson disease.This publication has 14 references indexed in Scilit:
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