Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age
- 1 March 2001
- journal article
- Published by Elsevier BV in Neurobiology of Aging
- Vol. 22 (2), 265-272
- https://doi.org/10.1016/s0197-4580(00)00234-7
Abstract
The chronological accumulation of mitochondrial dysfunction has been proposed as a potential mechanism in the physiological processes of aging. Cytochrome c oxidase deficient, succinate dehydrogenase positive muscle fibers containing high copy numbers of a mitochondrial DNA mutation are a pathological hallmark of mitochondrial DNA disorders. We show that there is an age-related increase in cytochrome c oxidase-deficient cells in both hippocampal pyramidal neurons and choroid plexus epithelial cells. We suggest that these cells contribute to the cell death and dysfunction in CNS aging.Keywords
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