Noncovalent Encapsulation Stabilities in Supramolecular Nanoassemblies
- 20 July 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 132 (31), 10683-10685
- https://doi.org/10.1021/ja105059g
Abstract
Exchange dynamics of lipophilic guest molecules, encapsulated in supramolecular nanoassemblies in aqueous solutions, have implications in evaluating the stability of drug delivery vehicles. This is because exchange dynamics is related to the propensity of a nanocarrier to be leaky. We describe a fluorescence resonance energy transfer (FRET) based method to evaluate guest exchange dynamics in the aqueous phase. We have utilized this method to analyze the stability of encapsulation in polymeric nanogels and other related amphiphilic nanoassemblies.This publication has 15 references indexed in Scilit:
- Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation CapabilitiesJournal of the American Chemical Society, 2010
- Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite CapabilitiesAngewandte Chemie-International Edition, 2009
- Impact of Nanotechnology on Drug DeliveryACS Nano, 2009
- Hydrogel nanoparticles in drug deliveryAdvanced Drug Delivery Reviews, 2008
- Block copolymer micelles as delivery vehicles of hydrophobic drugs: Micelle–cell interactionsJournal of Drug Targeting, 2006
- Synthesis and Characterization of Amine-Functionalized Polystyrene NanoparticlesMacromolecules, 2005
- Drug Delivery Systems: Entering the MainstreamScience, 2004
- A Facile Approach to Architecturally Defined Nanoparticles via Intramolecular Chain CollapseJournal of the American Chemical Society, 2002
- Swell gelsNature, 2002
- Molecular imprinting within hydrogelsAdvanced Drug Delivery Reviews, 2001