In the non-cirrhotic stage of nonalcoholic steatohepatitis, angioarchitecture of portal veins and lobular architecture are maintained
Open Access
- 28 March 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Virchows Archiv A Pathological Anatomy and Histopathology
- Vol. 462 (5), 533-540
- https://doi.org/10.1007/s00428-013-1402-8
Abstract
The morphogenesis of lobular restructuring to liver cirrhosis in nonalcoholic steatohepatitis (NASH) is yet to be clearly understood. Therefore, we observed tissue samples from three biopsies and one autopsy with NASH in the non-cirrhotic stage three-dimensionally to elucidate the evolution of fibrosis and the changes of angioarchitecture. Histologic reconstructions revealed that pericellular fibrosis developed around the central vein in the early stage and gradually progressed to arch-shaped band-like fibrosis connecting the central veins in the neighboring lobules. In contrast, the basic angioarchitecture of the portal vein in the portal tracts tended to be preserved in the non-cirrhotic stage, although the portal vein architecture was slightly altered as the portal tract underwent gradual fibrous expansion. In addition, a striking development of arteries originating from the portal tract was found in the fibrotic area around the central and sublobular veins. In summary, while central–central bridging fibrosis and ectopic arterial development were conspicuous, the lobular architecture was maintained relatively well in the non-cirrhotic stage of NASH because of only mildly damaged angioarchitecture of the portal veins. The process of lobular restructuring in NASH is considered to be different from that in chronic viral hepatitis in the non-cirrhotic stage.Keywords
This publication has 28 references indexed in Scilit:
- Late Nonalcoholic Fatty Liver Disease with Cirrhosis: A Pathologic Case of Lost or Mistaken IdentitySeminars in Liver Disease, 2012
- Centrizonal Arteries and Microvessels in Nonalcoholic SteatohepatitisThe American Journal of Surgical Pathology, 2011
- Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitisJournal of Hepatology, 2009
- Interobserver variation in the histopathological assessment of nonalcoholic steatohepatitisHepatology Research, 2005
- Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseJournal of Hepatology, 2005
- NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndromeJournal of Hepatology, 2002
- Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factorsJournal of Hepatology, 1990
- Angioarchitectural changes in a mixed nodular cirrhotic liver.Kanzo, 1989
- The pathology of diabetic hepatitisThe Journal of Pathology, 1988
- Morphologic features of hepatic injury in cardiac disease and shockJournal of Hepatology, 1986