Centrizonal Arteries and Microvessels in Nonalcoholic Steatohepatitis
- 1 September 2011
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Surgical Pathology
- Vol. 35 (9), 1400-1404
- https://doi.org/10.1097/pas.0b013e3182254283
Abstract
Correct classification of nonalcoholic steatohepatitis (NASH) liver biopsies is of critical importance and relies on correct orientation to microscopic liver architecture. Centrizonal arteries can cause central zones to be mistaken for portal tracts, especially in the setting of centrizonal ductular reaction, and result in either missed diagnosis or inaccurate staging of NASH. A total of 100 randomly selected biopsies from NASH Clinical Research Network participants (February 2005 to August 2006, fibrosis stage >1a) were evaluated for arteries and CD34-positive microvessels in the centrizonal region. Prevalence of both centrizonal arteries and CD34-positive microvessels was graded as 0 (none in central zones), 1 (1 to 2 central zones with vessels), 2 (P<0.001). Ductular reaction was a common finding (55%) in patients with central zone arteries. The presence of centrizonal arteries must be recognized to allow for correct orientation to liver architecture in NASH and, together with the finding of increased CD34-positive microvessel formation in higher-stage fibrosis, suggests a possible association between neoangiogenesis and NASH progression to cirrhosis.This publication has 27 references indexed in Scilit:
- Fibrosis correlates with a ductular reaction in hepatitis C: Roles of impaired replication, progenitor cells and steatosisJournal of Hepatology, 2005
- Expression of the hepatic endothelin system in human cirrhotic liversThe Journal of Pathology, 2004
- Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological LesionsThe American Journal of Gastroenterology, 1999
- Changes in type IV collagen content in livers of patients with alcoholic liver disease.1993
- Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast CarcinomaThe New England Journal of Medicine, 1991
- Quantitative aspects of portal-systemic and arteriovenous shunts within the liver in cirrhosisGastroenterology, 1987
- The scarring of the liver acini (Cirrhosis). Tridimensional and microcirculatory considerations.1983
- Pathologic aspects of cirrhosis. A review.1977
- The terminal distribution of the hepatic artery with special reference to arterio-portal anastomosis.1966
- Terminal distribution of the hepatic arteryThe Anatomical Record, 1953