Comparison of cefpodoxime proxetil release and antimicrobial activity from tablet formulations: Complexation with hydroxypropyl-β-cyclodextrin in the presence of water soluble polymer
- 15 October 2011
- journal article
- Published by Taylor & Francis Ltd in Drug Development and Industrial Pharmacy
- Vol. 38 (6), 689-696
- https://doi.org/10.3109/03639045.2011.621434
Abstract
This study aims to prove the complexation of cefpodoxime proxetil (CP) by hydroxypropyl-β-cyclodextrin (HP-β-CD) in the presence of sodium carboxymethyl cellulose (Na CMC), and makes a comparison of commercial tablets by dissolution and antimicrobial activity studies. The CP–HP-β-CD complex was prepared by kneading method and characterized by SEM, FTIR and DSC. The solubility method was used to investigate the effect of HP-β-CD and Na CMC on the solubility of CP. The complex tablets were prepared using direct compression method. Dissolution studies were performed with complex tablets and commercial tablets in pH 1.2, 4.5, 6.8 and 7.4 buffer solutions. It was observed that complexation occurred in all formulations, and HP-β-CD is able to increase CP solubility and dissolution rate of CP was improved from complex tablets, when compared with commercial tablets. Furthermore, the antimicrobial activity studies revealed that the CP–HP-β-CD complex and complex tablets were shown to have more effective antimicrobial activity than commercial tablets. It is evident from the results that complexation with HP-β-CD in the presence of Na CMC is feasible way to prepare a more efficient tablet formulation with improved dissolution and antimicrobial activity.Keywords
This publication has 31 references indexed in Scilit:
- Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complexEuropean Journal of Pharmaceutics and Biopharmaceutics, 2011
- A Solid-State Approach to Enable Early Development Compounds: Selection and Animsal Bioavailability Studies of an Itraconazole Amorphous Solid DispersionJournal of Pharmaceutical Sciences, 2010
- A Novel Prodrug Strategy for β-Dicarbonyl Carbon Acids: Syntheses and Evaluation of the Physicochemical Characteristics of C-Phosphoryloxymethyl (POM) and Phosphoryloxymethyloxymethyl (POMOM) Prodrug DerivativesJournal of Pharmaceutical Sciences, 2010
- Gliclazide Microcrystals Prepared by Two Methods of In Situ Micronization: Pharmacokinetic Studies in Diabetic and Normal RatsAAPS PharmSciTech, 2010
- Development of a new single dose extended release formulation of cefpodoxime proxetilAsian Pacific Journal of Tropical Medicine, 2010
- Effect of Milling on DSC Thermogram of Excipient Adipic AcidAAPS PharmSciTech, 2010
- Functionalized Titanium Oxide Surfaces with Phosphated Carboxymethyl Cellulose: Characterization and Bonelike Cell BehaviorBiomacromolecules, 2007
- Cyclodextrin Derivatives in PharmaceuticsCritical Reviews in Therapeutic Drug Carrier Systems, 1995
- In vitro activity of cefpodoxime compared with other oral cephalosporins tested against 5556 recent clinical isolates from five medical centersDiagnostic Microbiology and Infectious Disease, 1993
- A Review of the Pharmacokinetics of Cefpodoxime ProxetilDrugs, 1991