Development of a new single dose extended release formulation of cefpodoxime proxetil

Abstract

To develop floating microspheres of cefpodoxime proxetil (CP) in order to achieve an extended retention in the upper GIT for 12 hour. The microspheres were prepared by non aqueous solvent evaporation method using different ratios of cefpodoxime proxetil, hydroxyl propyl methyl cellulose (HPMC K4M) and ethyl cellulose (1:1:1, 1:1:2, 1:1:3, 1:1:4, 1:1:5 & 1:1:6), in the mixture of dichloromethane and ethanol at ratio of (1:1), with tween80 as the surfactant. The floating microspheres was extended over 10–12 hours and were characterized by particle size analysis (75–600μm), buoyancy percentage (68.1%–85.4%), drug entrapment efficiency (67.5%–88.8%), % yield (50.50%–77.31%) and in vitro drug release was studied for 12 hours. The floating microspheres show better result and it may be use full for prolong the drug release in stomach and improve the bioavailability.