TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS
- 1 November 1998
- journal article
- review article
- Published by Annual Reviews in Annual Review of Cell and Developmental Biology
- Vol. 14 (1), 167-196
- https://doi.org/10.1146/annurev.cellbio.14.1.167
Abstract
▪ Abstract Metazoans contain multiple types of muscle cells that share several common properties, including contractility, excitability, and expression of overlapping sets of muscle structural genes that mediate these functions. Recent biochemical and genetic studies have demonstrated that members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors play multiple roles in muscle cells to control myogenesis and morphogenesis. Like other MADS-box proteins, MEF2 proteins act combinatorially through protein-protein interactions with other transcription factors to control specific sets of target genes. Genetic studies in Drosophila have also begun to reveal the upstream elements of myogenic regulatory hierarchies that control MEF2 expression during development of skeletal, cardiac, and visceral muscle lineages. Paradoxically, MEF2 factors also regulate cell proliferation by functioning as endpoints for a variety of growth factor-regulated intracellular signaling pathways that are antagonistic to muscle differentiation. We discuss the diverse functions of this family of transcription factors, the ways in which they are regulated, and their mechanisms of action.Keywords
This publication has 91 references indexed in Scilit:
- Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammationNature, 1997
- Coordinate positioning of MEF2 and myogenin binding sitesGene, 1996
- Functional and Physical Interactions between Mammalian Achaete-Scute Homolog 1 and Myocyte Enhancer Factor 2AOnline Journal of Public Health Informatics, 1996
- Regional Chromosomal Assignments for Four Members of the MADS Domain Transcription Enhancer Factor 2 (MEF2) Gene Family to Human Chromosomes 15q26, 19p12, 5q14, and 1q12–q23Genomics, 1995
- MADS-box genes in plant ontogeny and phylogeny: Haeckel's ‘biogenetic law’ revisitedCurrent Opinion in Genetics & Development, 1995
- Myotube-specific Activity of the Human Aldolase A M-promoter Requires an Overlapping Binding Site For NF1 and MEF2 Factors in Addition to a Binding Site (M1) For Unknown ProteinsJournal of Molecular Biology, 1995
- Structure of serum response factor core bound to DNANature, 1995
- The Role of the CANNTG Promoter Element (E box) and the Myocyte‐enhancer‐binding‐factor‐2 (MEF‐2) Site in the Transcriptional Regulation of the Chick Myogenin GeneJBIC Journal of Biological Inorganic Chemistry, 1995
- In vivo protein‐DNA interactions at the c‐jun promoter in quiescent and serum‐stimulated fibroblastsJournal of Cellular Biochemistry, 1995
- Analysis of upstream regulatory regions required for the activities of two promoters of the rat aldolase A geneFEBS Letters, 1991