Structure of serum response factor core bound to DNA
- 1 August 1995
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 376 (6540), 490-498
- https://doi.org/10.1038/376490a0
Abstract
The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.Keywords
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