The microenvironment in breast cancer progression: biology and implications for treatment
Open Access
- 31 December 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Breast Cancer Research
- Vol. 13 (6), 1-11
- https://doi.org/10.1186/bcr2912
Abstract
Breast cancer comprises a heterogeneous group of malignancies derived from the ductal epithelium. The microenvironment of these cancers is now recognized as a critical participant in tumor progression and therapeutic responses. Recent data demonstrate significant gene expression and epigenetic alterations in cells composing the microenvironment during disease progression, which can be explored as biomarkers and targets for therapy. Indeed, gene expression signatures derived from tumor stroma have been linked to clinical outcomes. There is increasing interest in translating our current understanding of the tumor microenvironment to the development of novel therapies.This publication has 71 references indexed in Scilit:
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