Calcium-Mediated Reduction of Ionic Currents: A Biophysical Memory Trace
- 30 November 1984
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 226 (4678), 1037-1045
- https://doi.org/10.1126/science.6093258
Abstract
Learning behavior similar to vertebrate classical conditioning was demonstrated for the mollusc Hermissenda crassicornis. Postsynaptic membrane changes within well-defined neural systems that mediate the learning play a casual role in recording the learned association for later recall. Specific ionic currents in neural tissue undergo transformations lasting days after associative training with physiologic stimuli. During acquisition the intracellular calcium increases; this increase is accompanied by specific potassium current reduction that lasts for days after conditioning. The increase of calcium enhances calmodulin-dependent phosphorylation of proteins that either regulate or are part of ion channels. These currents and the conditions that precede their transformation occur in many types of vertebrate neurons, and hence this biophysical basis of Hermissenda learning could have relevance for species other than the gastropod studied.Keywords
This publication has 67 references indexed in Scilit:
- A Cellular Mechanism of Classical Conditioning in Aplysia : Activity-Dependent Amplification of Presynaptic FacilitationScience, 1983
- Molecular Biology of Learning: Modulation of Transmitter ReleaseScience, 1982
- Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neuronesNature, 1982
- CELLULAR ANALYSIS OF A GASTROPOD (HERMISSENDA CRASSICORNIS) MODEL OF ASSOCIATIVE LEARNINGThe Biological Bulletin, 1980
- Associative Behavioral Modification in Hermissenda : Cellular CorrelatesScience, 1980
- Voltage-Dependent Calcium and Potassium Ion Conductances: A Contingency Mechanism for an Associative Learning ModelScience, 1979
- Maze training effects on dendritic branching in occipital cortex of adult ratsBehavioral and Neural Biology, 1979
- Learning: Classical and Avoidance Conditioning in the Mollusk PleurobranchaeaScience, 1973
- Responses of Photoreceptors in Hermissenda The Journal of general physiology, 1972
- An analysis of leg position learning in the cockroach yoked controlPhysiology & Behavior, 1971