Antiobesity Effects of Salvia plebeia R. Br. Extract in High-Fat Diet-Induced Obese Mice
- 1 November 2016
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Medicinal Food
- Vol. 19 (11), 1048-1056
- https://doi.org/10.1089/jmf.2016.3763
Abstract
This study was designed to investigate the antiobesity effects of Salvia plebeia R. Br. ethanolic extracts (SPE) in mice fed high-fat diets (HFD). Male C57BL/6J mice were randomly assigned to four groups: normal diet (Chow), high-fat diet (HFD, 45% fat), HFD+SPE 200 (200 mg/kg b.w.), and HFD+SPE 400 (400 mg/kg b.w.). Extracts were administered orally every day for 8 weeks. Increases in body/fat weight and feed efficiency ratio were monitored in all mice. In addition, obesity resulting from feeding HFD to the mice was confirmed by the increase of glucose level, aspartate transaminase, alanine transaminase, triglyceride (TG), high-density lipoprotein cholesterol, very low-density lipoprotein-c, leptin, and adiponectin in blood. The SPE-treated mice gained less body and mesenteric/subcutaneous adipose tissues weights and had lower TG, very low-density lipoprotein cholesterol, leptin, and glucose level in serum, compared to the HFD group. Moreover, histopathological examinations revealed that the size of adipocytes in liver and adipose tissue was significantly decreased by SPE, compared to the HFD group. The expression of adipogenesis transcription factors (e.g., peroxisome proliferator activated receptor γ and CCAAT/enhancer binding protein α) and lipogenesis-related target genes (adipocyte fatty acid-binding protein 2, lipoprotein lipase, fatty acid synthase, and sterol regulatory element-binding transcription factor 1c) in HFD-induced obese mice was decreased by SPE treatment. These results suggest that SPE attenuates the fat accumulation in HFD-induced obese mice by suppressing the expressions of genes related to adipogenesis and lipogenesis activity. Therefore, SPE could be developed as a potential therapy for reduction of body weight and antiobesity intervention.Keywords
This publication has 27 references indexed in Scilit:
- Anti-Inflammatory Activity of Salvia plebeia R. Br. Leaf through Heme Oxygenase-1 Induction in LPS-Stimulated RAW264.7 MacrophagesJournal of the Korean Society of Food Science and Nutrition, 2012
- Homoplantaginin Modulates Insulin Sensitivity in Endothelial Cells by Inhibiting InflammationBiological & Pharmaceutical Bulletin, 2012
- Hispidulin Sensitizes Human Ovarian Cancer Cells to TRAIL-Induced Apoptosis by AMPK Activation Leading to Mcl-1 Block in TranslationJournal of Agricultural and Food Chemistry, 2010
- Hispidulin Potently Inhibits Human Glioblastoma Multiforme Cells through Activation of AMP-Activated Protein Kinase (AMPK)Journal of Agricultural and Food Chemistry, 2010
- The effect of carbamazepine treatment on serum leptin levelsEpilepsy Research, 2009
- Causes and control of excess body fatNature, 2009
- Pharmacotherapy of obesity: emerging drugs and targetsEmerging Therapeutic Targets, 2008
- Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatographyJournal of Pharmaceutical and Biomedical Analysis, 2008
- Thermogenic and metabolic antiobesity drugs: rationale and opportunitiesDiabetes, Obesity and Metabolism, 2006
- Obesity as a medical problemNature, 2000