MHC class I in activity-dependent structural and functional plasticity
- 1 May 2004
- journal article
- Published by Cambridge University Press (CUP) in Neuron Glia Biology
- Vol. 1 (3), 283-289
- https://doi.org/10.1017/s1740925x05000128
Abstract
Members of the major histocompatibility complex (MHC) class I family of proteins are well known for their central role in the adaptive immune system, where they present self and non-self peptides for immune surveillance. Although the brain has been long considered immune privileged, in part because of an apparent lack of neuronal MHC class I, it has since been shown that MHC class I proteins are expressed by normal, uninfected neurons. Moreover, expression of MHC class I is unusually dynamic in the developing and adult brain, and MHC class I levels in neurons can be regulated by endogenous and exogenous electrical activity. Unexpectedly, several recent studies find that MHC class I is required for distinct activity-dependent events during brain development, adult plasticity, and in response to injury. Together, these studies indicate a novel role for MHC class I proteins in translating electrical activity into changes in synaptic strength and neuronal connectivity in vivo.Keywords
This publication has 38 references indexed in Scilit:
- Major Histocompatibility Complex (MHC) Class I Gene Expression in Single Neurons of the Central Nervous System: Differential Regulation by Interferon (IFN)-γ and Tumor Necrosis Factor (TNF)-αThe Journal of Experimental Medicine, 1997
- IFN-γ induces expression of MHC class I molecules in adult mouse dorsal root ganglion neuronesNeuroReport, 1996
- Upregulation of class I major histocompatibility complex gene expression in primary sensory neurons, satellite cells, and Schwann cells of mice in response to acute but not latent herpes simplex virus infection in vivo.The Journal of Experimental Medicine, 1994
- Differentiation of an immortalized CNS neuronal cell line decreases their susceptibility to cytotoxic T cell lysis in vitroJournal of Neuroimmunology, 1994
- Assembly and Intracellular Transport of MHC Class I MoleculesAnnual Review of Cell Biology, 1993
- Viral Persistence in Neurons Explained by Lack of Major Histocompatibility Class I ExpressionScience, 1991
- β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cellsNature, 1990
- Functional Implications of Class I MHC Modulation in Neural TissueAnnals of the New York Academy of Sciences, 1988
- Axotomy induces MHC class I antigen expression on rat nerve cellsNeuroscience Letters, 1988
- Inducible expression of H–2 and Ia antigens on brain cellsNature, 1984