β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells
- 1 April 1990
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 344 (6268), 742-746
- https://doi.org/10.1038/344742a0
Abstract
Mice homozygous for a beta 2-microglobulin gene disruption do not express any detectable beta 2-m protein. They express little if any functional major histocompatibility complex (MHC) class I antigen on the cell surface yet are fertile and apparently healthy. They show a normal distribution of gamma delta, CD4+8+ and CD4+8- T cells, but have no mature CD4-8+ T cells and are defective in CD4-8+ T cell-mediated cytotoxicity. Our results strongly support earlier evidence that MHC class I molecules are crucial for positive selection of T cell antigen receptor alpha beta+ CD4-8+ T cells in the thymus and call into question the non-immune functions that have been ascribed to MHC class I molecules.Keywords
This publication has 55 references indexed in Scilit:
- Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridomaNature, 1989
- The Structure, Function, and Molecular Genetics of the gamma/delta T Cell ReceptorAnnual Review of Immunology, 1989
- Positive selection of CD4-CD8+ T cells in the thymus of normal miceNature, 1989
- The thymus selects the useful, neglects the useless and destroys the harmfulImmunology Today, 1989
- The T-cell repertoire for antigen and MHCImmunology Today, 1988
- Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic miceNature, 1988
- The Developmental Biology of T LymphocytesAnnual Review of Immunology, 1988
- Expression of H-2Db on the cell surface in the absence of detectable beta 2 microglobulin.The Journal of Experimental Medicine, 1984
- Interaction between major histocompatibility complex antigens and epidermal growth factor receptors on human cells.The Journal of cell biology, 1984
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970