Progestins of today and tomorrow
- 19 August 2022
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Obstetrics and Gynecology
- Vol. 34 (6), 344-350
- https://doi.org/10.1097/gco.0000000000000819
Abstract
Purpose of review To review the current literature on the multiple types and uses of progestins in reproductive healthcare. Recent findings Progestins for contraceptive use are available in multiple forms, with the ongoing development of transdermal, intravaginal, and male contraception formulations. Noncontraceptive use of progestins often overlaps with contraceptive indications, which allows for simultaneous multipurpose progestin use, especially in reproductive-aged patients. More studies are needed to determine contraceptive doses of progestins used for noncontraceptive purposes. Side effect profiles of progestins are dependent on their formulation and cross-reactivity with other steroid receptors. Development of newer progestins includes manipulating pharmacologic properties to avoid undesired side effects. Summary Progestins have multiple uses in reproductive healthcare, including contraception, menstrual suppression, endometrial protection, and hormonal replacement therapy. The development of progestins for these indications can expand therapy for people with contraindications to estrogen-based hormonal therapy.Keywords
This publication has 53 references indexed in Scilit:
- Ovulation inhibition doses of progestins: a systematic review of the available literature and of marketed preparations worldwideContraception, 2011
- Continuation Rates and Complications of Intrauterine Contraception in Women Diagnosed With Bipolar DisorderObstetrics & Gynecology, 2011
- Evaluation and management of acute menorrhagia in women with and without underlying bleeding disorders: consensus from an international expert panelEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2011
- Safety and efficacy of a single-rod etonogestrel implant (Implanon): results from 11 international clinical trialsFertility and Sterility, 2009
- The effects of Implanon® on menstrual bleeding patternsThe European Journal of Contraception & Reproductive Health Care, 2008
- The safety of a drospirenone-containing oral contraceptive: final results from the European Active Surveillance study on Oral Contraceptives based on 142,475 women-years of observationContraception, 2007
- Ovarian cysts in users of Implanon® and Jadelle® subdermal contraceptive implantsContraception, 2006
- Classification and pharmacology of progestinsMaturitas, 2003
- Depressive symptoms and Depo-Provera®Contraception, 1998
- Depression in users of depo-medroxyprogesterone acetateContraception, 1995