The functional role of the β‐subunit in the maturation and intracellular transport of Na,K‐ATPase
- 1 July 1991
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 285 (2), 189-193
- https://doi.org/10.1016/0014-5793(91)80801-9
Abstract
The minimal functional enzyme unit of Na,K-ATPase consists of an alpha-beta complex. The alpha-subunit bears all functional domains of the enzyme and so far a regulatory role for the beta-subunit in the catalytic cycle has not been established. On the other hand, increasing experimental evidence suggests that the beta-subunit is an indispensable element for the structural and functional maturation of the enzyme as well as its intracellular transport to the plasma membrane. This brief review summarizes the experimental data supporting the hypothesis that assembly of the beta-subunit is needed for the alpha-subunit to acquire the correct, stable configuration necessary for the acquisition of functional properties and its exit from the ER.This publication has 62 references indexed in Scilit:
- Molecular cloning of the β‐subunit of the Na,K‐ATPase in the brine shrimp, ArtemiaFEBS Letters, 1990
- Mutual dependence of Na,K‐ATPase α‐ and β‐subunits for correct posttranslational processing and intracellular transportFEBS Letters, 1990
- The energy coupled exchange of Na+ for K+ across the cell membraneFEBS Letters, 1990
- Subunit assembly and functional maturation of Na,K-ATPaseThe Journal of Membrane Biology, 1990
- Isozymes of the Na+/K+-ATPaseBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989
- Regulation of Protein Export From the Endoplasmic ReticulumAnnual Review of Cell Biology, 1988
- Role of the Na,K-ATPaseβ-subunit in the cellular accumulation and maturation of the enzyme as assessed by glycosylation inhibitorsThe Journal of Membrane Biology, 1988
- Structural basis for E1–E2 conformational transitions in Na, K-pump and Ca-pump proteinsThe Journal of Membrane Biology, 1988
- Molecular cloning and sequence analysis of the (Na+ + K+)-ATPase β subunit from dog kidneyBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1987
- Orientation of the β subunit polypeptide of (Na+ + K+)ATPase in the cell membraneBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986