Mutual dependence of Na,K‐ATPase α‐ and β‐subunits for correct posttranslational processing and intracellular transport
- 20 August 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 269 (1), 105-108
- https://doi.org/10.1016/0014-5793(90)81130-g
Abstract
In this study, we have followed the fate of newly synthesized α- and β-subunits of Na,K-ATPase in Xenopus oocytes injected with α and/or β cRNA to examine whether assembly of the two subunits is needed for a correct folding and/or for intracellular transport of Na,K-ATPase. Our data indicate that (1) assembly of α- and β-subunits occurs at the level of the ER, (2) β-subunits are needed for the newly synthesized α-subunit to adopt a stable configuration and (3) α- and β-subunits mutually depend on each other to be transported out of the ER.Keywords
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