Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry
Open Access
- 1 March 2019
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 5 (3), eaaw0873
- https://doi.org/10.1126/sciadv.aaw0873
Abstract
Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O2-mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O2-mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.Keywords
Funding Information
- National Science Foundation (ECCS-1542205)
- National Science Foundation (DMR-1720139)
This publication has 57 references indexed in Scilit:
- Peripheral tissue oximetry: comparing three commercial near-infrared spectroscopy oximeters on the forearmJournal of Clinical Monitoring and Computing, 2013
- Imaging local neuronal activity by monitoring PO2 transients in capillariesNature Medicine, 2013
- Near-Infrared Optical Mammography for Breast Cancer Detection with Intrinsic ContrastAnnals of Biomedical Engineering, 2011
- Quantitative tissue oxygen measurement in multiple organs using 19F MRI in a rat modelMagnetic Resonance in Medicine, 2011
- Tissue Oximetry Monitoring in Microsurgical Breast Reconstruction Decreases Flap Loss and Improves Rate of Flap SalvagePlastic and Reconstructive Surgery, 2011
- Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronicsNature Materials, 2010
- Quantitative In Vivo Imaging of Tissue Absorption, Scattering, and Hemoglobin Concentration in Rat Cortex Using Spatially Modulated Structured LightPublished by Taylor & Francis Ltd ,2009
- Simultaneous Molecular and Hypoxia Imaging of Brain Tumors In Vivo Using Spectroscopic Photoacoustic TomographyProceedings of the IEEE, 2008
- Wounds: An Overview of the Role of OxygenAntioxidants and Redox Signaling, 2007
- DECREASED SUPPLY-DEPENDENT OXYGEN CONSUMPTION IN THE SKELETAL MUSCLE OF THE SPONTANEOUSLY HYPERTENSIVE RAT DURING ACUTE HYPOXIAShock, 2006