Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics
Top Cited Papers
- 18 April 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Materials
- Vol. 9 (6), 511-517
- https://doi.org/10.1038/nmat2745
Abstract
Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable and surgical devices.Keywords
This publication has 30 references indexed in Scilit:
- Water-insoluble silk films with silk I structureActa Biomaterialia, 2010
- Silicon electronics on silk as a path to bioresorbable, implantable devicesApplied Physics Letters, 2009
- Human cortical prostheses: lost in translation?Neurosurgical Focus, 2009
- Human neocortical electrical activity recorded on nonpenetrating microwire arrays: applicability for neuroprosthesesNeurosurgical Focus, 2009
- Monitoring Hippocampus Electrical Activity In Vitro on an Elastically Deformable Microelectrode ArrayJournal of Neurotrauma, 2009
- Integrated wireless neural interface based on the Utah electrode arrayBiomedical Microdevices, 2008
- Modification of silk fibroin using diazonium coupling chemistry and the effects on hMSC proliferation and differentiationBiomaterials, 2008
- Cellular Mechanisms Underlying Stimulus-Dependent Gain Modulation in Primary Visual Cortex Neurons In VivoNeuron, 2008
- A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cordBiomedical Microdevices, 2007
- Stimulus Feature Selectivity in Excitatory and Inhibitory Neurons in Primary Visual CortexJournal of Neuroscience, 2007