Binding sugars: from natural lectins to synthetic receptors and engineered neolectins
- 25 January 2013
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 42 (11), 4798-4813
- https://doi.org/10.1039/c2cs35435g
Abstract
The large diversity and complexity of glycan structures together with their crucial role in many biological or pathological processes require the development of new high-throughput techniques for analyses. Lectins are classically used for characterising, imaging or targeting glycoconjugates and, when printed on microarrays, they are very useful tools for profiling glycomes. Development of recombinant lectins gives access to reliable and reproducible material, while engineering of new binding sites on existing scaffolds allows tuning of specificity. From the accumulated knowledge on protein–carbohydrate interactions, it is now possible to use nucleotide and peptide (bio)synthesis for producing new carbohydrate-binding molecules. Such a biomimetic approach can also be addressed by boron chemistry and supra-molecular chemistry for the design of fully artificial glycosensors.This publication has 189 references indexed in Scilit:
- The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cellsVirology, 2011
- Development of recombinant Aleuria aurantia lectins with altered binding specificities to fucosylated glycansBiochemical and Biophysical Research Communications, 2011
- Galectins as Pattern Recognition Receptors: Structure, Function, and EvolutionAdvances in experimental medicine and biology, 2011
- Aptamer in Bioanalytical ApplicationsAnalytical Chemistry, 2011
- A New Class of Fluorescent Boronic Acids That Have Extraordinarily High Affinities for Diols in Aqueous Solution at Physiological pHChemistry – A European Journal, 2010
- Synthesis and carbohydrate binding studies of fluorescent α-amidoboronic acids and the corresponding bisboronic acidsBioorganic & Medicinal Chemistry, 2010
- Carbohydrate recognition by boronolectins, small molecules, and lectinsMedicinal Research Reviews, 2009
- A Synthetic Lectin for O‐Linked β‐N‐AcetylglucosamineAngewandte Chemie-International Edition, 2009
- DNA aptamers bind specifically and selectively to (1→3)-β-d-glucansBiochemical and Biophysical Research Communications, 2009
- Analysis of Cell Surface Carbohydrate Expression Patterns in Normal and Tumorigenic Human Breast Cell Lines Using Lectin ArraysAnalytical Chemistry, 2007