Carbohydrate recognition by boronolectins, small molecules, and lectins
- 16 March 2009
- journal article
- review article
- Published by Wiley in Medicinal Research Reviews
- Vol. 30 (2), 171-257
- https://doi.org/10.1002/med.20155
Abstract
Carbohydrates are known to mediate a large number of biological and pathological events. Small and macromolecules capable of carbohydrate recognition have great potentials as research tools, diagnostics, vectors for targeted delivery of therapeutic and imaging agents, and therapeutic agents. However, this potential is far from being realized. One key issue is the difficulty in the development of “binders” capable of specific recognition of carbohydrates of biological relevance. This review discusses systematically the general approaches that are available in developing carbohydrate sensors and “binders/receptors,” and their applications. The focus is on discoveries during the last 5 years. © 2009 Wiley Periodicals, Inc. Med Res Rev, 30, No. 2, 171–257, 2010Keywords
This publication has 180 references indexed in Scilit:
- Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasisClinical & Experimental Metastasis, 2007
- A Chemomechanical Polymer that Functions in Blood Plasma with High Glucose SelectivityAngewandte Chemie, 2006
- Qualitative and quantitative alterations of cell surface carbohydrate residues during epidermal morphogenesisBrain Structure and Function, 2005
- Glycosylation profile of integrin α3β1 changes with melanoma progressionBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2003
- Boronic Acid Receptors for α-Hydroxycarboxylates: High Affinity of Shinkai's Glucose Receptor for TartrateThe Journal of Organic Chemistry, 2002
- Expression of Carbohydrate Antigens in Advanced-Stage Ovarian Carcinomas and Their Metastases—A Clinicopathologic StudyGynecologic Oncology, 2000
- The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissuesSeminars in Cancer Biology, 1999
- Anatomy and evolution of proteins displaying the viral capsid jellyroll topologyJournal of Molecular Biology, 1992
- Cis-aconityl spacer between daunomycin and macromolecular carriers: A model of pH-sensitive linkage releasing drug from a lysosomotropic conjugateBiochemical and Biophysical Research Communications, 1981
- Synthesis of a fluorescent boronic acid which reversibly binds to cell walls and a diboronic acid which agglutinates erythrocytesBiochemical and Biophysical Research Communications, 1980