Genetic Basis of Tetracycline and Minocycline Resistance in Potentially Probiotic Lactobacillus plantarum Strain CCUG 43738

Abstract
The potentially probiotic strain Lactobacillus plantarum CCUG 43738, which displayed atypical phenotypic resistance to tetracycline (MIC, 512 μg/ml) and minocycline (MIC, 256 μg/ml), was found to contain a tet (S) gene located on a plasmid of approximately 14 kb. Plasmid curing with novobiocin eliminated this plasmid and restored the tetracycline-susceptible phenotype of the host strain.

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