Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen
Open Access
- 25 November 1994
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 266 (5189), 1376-1380
- https://doi.org/10.1126/science.7973727
Abstract
GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.Keywords
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