Creative blocks: cell-cycle checkpoints and feedback controls
- 1 October 1992
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 359 (6396), 599-601
- https://doi.org/10.1038/359599a0
Abstract
Before division, cells must ensure that they finish DNA replication, DNA repair and chromosome segregation. They do so by using feedback controls which can detect the failure to complete replication, repair or spindle assembly to arrest the progress of the cell cycle at one of three checkpoints. Failures in feedback controls can contribute to the generation of cancer.This publication has 70 references indexed in Scilit:
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