Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology
Open Access
- 5 July 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular Psychiatry
- Vol. 16 (10), 987-995
- https://doi.org/10.1038/mp.2011.76
Abstract
Particulate matter air pollution is a pervasive global risk factor implicated in the genesis of pulmonary and cardiovascular disease. Although the effects of prolonged exposure to air pollution are well characterized with respect to pulmonary and cardiovascular function, comparatively little is known about the impact of particulate matter on affective and cognitive processes. The central nervous system may be adversely affected by activation of reactive oxygen species and pro-inflammatory pathways that accompany particulate matter pollution. Thus, we investigated whether long-term exposure to ambient fine airborne particulate matter (2.5)) affects cognition, affective responses, hippocampal inflammatory cytokines and neuronal morphology. Male mice were exposed to either PM2.5 or filtered air (FA) for 10 months. PM2.5 mice displayed more depressive-like responses and impairments in spatial learning and memory as compared with mice exposed to FA. Hippocampal pro-inflammatory cytokine expression was elevated among PM2.5 mice. Apical dendritic spine density and dendritic branching were decreased in the hippocampal CA1 and CA3 regions, respectively, of PM2.5 mice. Taken together, these data suggest that long-term exposure to particulate air pollution levels typical of exposure in major cities around the globe can alter affective responses and impair cognition.Keywords
This publication has 47 references indexed in Scilit:
- Sex bias in neuroscience and biomedical researchNeuroscience & Biobehavioral Reviews, 2011
- Effect of Early Particulate Air Pollution Exposure on Obesity in MiceArteriosclerosis, Thrombosis, and Vascular Biology, 2010
- Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissuesAmerican Journal of Physiology-Cell Physiology, 2010
- Secondhand Smoke Policy and the Risk of DepressionAnnals of Behavioral Medicine, 2010
- Secondhand Smoke Exposure and Depressive SymptomsPsychosomatic Medicine, 2010
- Diesel exhaust exposure induces angiogenesisToxicology Letters, 2009
- Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharideBrain, Behavior, and Immunity, 2009
- Air pollution and cardiac remodeling: a role for RhoA/Rho-kinaseAmerican Journal of Physiology-Heart and Circulatory Physiology, 2009
- Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative DiseaseBiological Psychiatry, 2009
- IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stressProceedings of the National Academy of Sciences of the United States of America, 2008