IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Open Access
- 15 January 2008
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 105 (2), 751-756
- https://doi.org/10.1073/pnas.0708092105
Abstract
Stress decreases neurogenesis in the adult hippocampus, and blockade of this effect is required for the actions of antidepressants in behavioral models of depression. However, the mechanisms underlying these effects of stress have not been identified. Here, we demonstrate an essential role for the proinflammatory cytokine IL-1β. Administration of IL-1β or acute stress suppressed hippocampal cell proliferation. Blockade of the IL-1β receptor, IL-1RI, by using either an inhibitor or IL-1RI null mice blocks the antineurogenic effect of stress and blocks the anhedonic behavior caused by chronic stress exposure. In vivo and in vitro studies demonstrate that hippocampal neural progenitor cells express IL-1RI and that activation of this receptor decreases cell proliferation via the nuclear factor-κB signaling pathway. These findings demonstrate that IL-1β is a critical mediator of the antineurogenic and depressive-like behavior caused by acute and chronic stress.This publication has 78 references indexed in Scilit:
- Neurogenesis and Helplessness Are Mediated by Controllability in Males But Not in FemalesBiological Psychiatry, 2007
- Biomarkers of exposure to environmental tobacco smoke in infantsBiomarkers, 2007
- Stress and adult neurogenesisHippocampus, 2006
- Evaluation of a counseling method for the prevention of child exposure to tobacco smoke: an example of client-centered communicationPreventive Medicine, 2004
- Intervention to reduce environmental tobacco smoke exposure in Latino children: null effects on hair biomarkers and parent reportsTobacco Control, 2004
- A simple and reliable method for the determination of nicotine and cotinine in teeth by gas chromatography/mass spectrometryRapid Communications in Mass Spectrometry, 2003
- Health effects of passive smoking 10: Summary of effects of parental smoking on the respiratory health of children and implications for researchThorax, 1999
- Environmental tobacco smoke exposure and health effects in children: results from the 1991 National Health Interview SurveyTobacco Control, 1996
- Interleukin-1 and Tumor Necrosis Factor-α Synergistically Mediate Neurotoxicity: Involvement of Nitric Oxide and of N-Methyl-D-aspartate ReceptorsBrain, Behavior, and Immunity, 1995
- The axial distribution of nicotine content along hair shaft as an indicator of changes in smoking behaviour: evaluation in a smoking‐ cessation programme with or without the aid of nicotine chewing gum.British Journal of Clinical Pharmacology, 1995