Analog Noise Reduction in Enzymatic Logic Gates
- 7 July 2009
- journal article
- Published by American Chemical Society (ACS) in The Journal of Physical Chemistry B
- Vol. 113 (30), 10472-10479
- https://doi.org/10.1021/jp904585x
Abstract
In this work, we demonstrate both experimentally and theoretically that the analog noise generation by a single enzymatic logic gate can be dramatically reduced to yield gate operation with virtually no input noise amplification. We demonstrate that when a cosubstrate with a much smaller affinity than the primary substrate is used, a negligible increase in the noise output from the logic gate is obtained, as compared to the input noise level. Our general theoretical conclusions were confirmed by experimental realizations of the AND logic gate based on the enzyme horseradish peroxidase using hydrogen peroxide as the substrate, with 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) or ferrocyanide as cosubstrates with vastly different rate constants.Keywords
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