Molecularly Imprinted Polymers Doped with Carbon Nanotube with Aid of Metal-Organic Gel for Drug Delivery Systems
- 10 September 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Pharmaceutical Research
- Vol. 37 (10), 1-14
- https://doi.org/10.1007/s11095-020-02902-z
Abstract
Purpose The incidence of breast cancer worldwide has been on the rise since the late 1970s, and it has become a common tumor that threatens women's health. Aminoglutethimide (AG) is a common treatment of breast cancer. However, current treatments require frequent dosing that results in unstable plasma concentration and low bioavailability, risking serious adverse reactions. Our goal was to develop a molecularly imprinted polymer (MIP) based delivery system to control the release of AG and demonstrate the availability of this drug delivery system (DDS), which was doped with carbon nanotube with aid of metal-organic gel. Methods Preparation of MIP was optimized by key factors including composition of formula, ratio of monomers and drug loading concentration. Results By using multi-walled carbon nanotubes (MWCNT) and metal-organic gels (MOGs), MIP doubled the specific surface area, pore volume tripled and the IF was 1.6 times than the reference. Compared with commercial tablets, the relative bioavailability was 143.3% and a more stable release appeared. Conclusions The results highlight the influence of MWCNT and MOGs on MIP, which has great potential as a DDS.Keywords
Funding Information
- National Natural Science Foundation of China (21775109)
- Natural Science Foundation of Tianjin (19JCZDJC36400)
This publication has 41 references indexed in Scilit:
- Molecularly imprinted silica prepared with immiscible ionic liquid as solvent and porogen for selective recognition of testosteroneTalanta, 2008
- Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopyProceedings of the National Academy of Sciences of the United States of America, 2008
- Macroporous polymer monoliths fabricated by using a metal–organic coordination gel templateChemical Communications, 2007
- Efficient preparation and improved sensitivity of molecularly imprinted polymers using room temperature ionic liquidsChemical Communications, 2006
- A metal–organic gel used as a template for a porous organic polymerChemical Communications, 2005
- Drug Delivery Systems: Entering the MainstreamScience, 2004
- Characterization of the Imprint Effect and the Influence of Imprinting Conditions on Affinity, Capacity, and Heterogeneity in Molecularly Imprinted Polymers Using the Freundlich Isotherm-Affinity Distribution AnalysisAnalytical Chemistry, 2004
- Ligand-targeted liposomesAdvanced Drug Delivery Reviews, 1998
- Treatment with formestane alone and in combination with aminoglutethimide in heavily pretreated breast cancer patients: Clinical and endocrine effectsEuropean Journal of Cancer, 1996
- A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discsJournal of Controlled Release, 1987