Effects of Grape Seed Proanthocyanidin Extracts on Aortic Pulse Wave Velocity in Streptozocin Induced Diabetic Rats
- 23 June 2009
- journal article
- Published by Oxford University Press (OUP) in Bioscience, Biotechnology, and Biochemistry
- Vol. 73 (6), 1348-1354
- https://doi.org/10.1271/bbb.90008
Abstract
Grape seed proanthocyanidin extracts (GSPEs) have been reported to be effective in treating arteriosclerosis, while little is known about therapeutic agents against diabetic macrovascular complications. We used streptozocin to induce diabetic rats. GSPEs (250 mg/kg of body weight) were administrated to diabetic rats for 24 weeks. Aortic blood pressure and pulse wave velocity (PWV) were determined in anesthetized rats. Serum glycated hemoglobin and advanced glycation end products (AGEs) were determined. An electronic microscope was used to observe the changes in aortic ultrastructure. Immunohistochemistry was used to evaluate the receptor of advanced glycation end product (RAGE) protein expression in aortic tissue. GSPEs significantly decreased aortic PWV, blood pressure, and aortic medial thickness (P<0.05), and inhibited the migration of vascular smooth muscle cells. GSPEs significantly reduced the AGEs (P<0.05) and the expression of RAGE in aortas of diabetic rats. GSPEs play an important role against diabetic macrovascular complications. This study may provide a new recognition of natural medicine for the treatment of diabetic macrovascular complications.Keywords
This publication has 45 references indexed in Scilit:
- Back‐regulation of six oxidative stress proteins with grape seed proanthocyanidin extracts in rat diabetic nephropathyJournal of Cellular Biochemistry, 2008
- Common crossroads in diabetes managementOsteopathic Medicine and Primary Care, 2008
- Grape Seed Proanthocyanidin Extracts Inhibit Vascular Cell Adhesion Molecule Expression Induced by Advanced Glycation End Products Through Activation of Peroxisome Proliferators-Activated Receptor γJournal of Cardiovascular Pharmacology, 2007
- Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosisDiabetologia, 2007
- The prevalence of macrovascular complications among diabetic patients in the United Arab EmiratesCardiovascular Diabetology, 2007
- Selective Inhibition by Grape Seed Proanthocyanidin Extracts of Cell Adhesion Molecule Expression Induced by Advanced Glycation End Products in Endothelial CellsJournal of Cardiovascular Pharmacology, 2006
- Pioglitazone Improves Aortic Wall Elasticity in a Rat Model of Elastocalcinotic ArteriosclerosisHypertension, 2005
- Aortic Pulse-Wave Velocity and Its Relationship to Mortality in Diabetes and Glucose IntoleranceCirculation, 2002
- Endothelial dysfunction in diabetesBritish Journal of Pharmacology, 2000
- A reduced elastic modulus of vascular wall components in hypertension?Hypertension, 1992