FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development
- 1 April 1994
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 264 (5155), 104-107
- https://doi.org/10.1126/science.7908145
Abstract
The apical ectodermal ridge permits growth and elongation of amniote limb buds; removal causes rapid changes in mesodermal gene expression, patterned cell death, and truncation of the limb. Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development. A bioassay for FGFs demonstrated that FGF-2 was the only detectable FGF in chick limb bud extracts. By distribution and bioactivity, FGF-2 is the prime candidate for the chick limb bud apical ridge growth signal.Keywords
This publication has 27 references indexed in Scilit:
- FGF-4 and BMP-2 have opposite effects on limb growthNature, 1993
- bFGF induces its own gene expression in astrocytic and hippocampal cell culturesNeuroReport, 1992
- Fibroblast growth factor receptor levels decrease during chick embryogenesis.The Journal of cell biology, 1990
- An in vivo model for study of the angiogenic effects of basic fibroblast growth factorBiochemical and Biophysical Research Communications, 1987
- Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblastsBiochemistry, 1986
- Spatial and temporal patterns of cell death in limb bud mesoderm after apical ectodermal ridge removalDevelopmental Biology, 1982
- Interaction between limb bud ectoderm and mesoderm in the chick embryo. III. Experiments with polydactylous limbsJournal of Experimental Zoology, 1956
- Ectoderm — mesoderm relationship in the development of the chick embryo limb budJournal of Experimental Zoology, 1955
- The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectodermJournal of Experimental Zoology, 1948