Evaluation of gastrointestinal drug supersaturation and precipitation: Strategies and issues
- 26 November 2012
- journal article
- review article
- Published by Elsevier BV in International Journal of Pharmaceutics
- Vol. 453 (1), 25-35
- https://doi.org/10.1016/j.ijpharm.2012.11.026
Abstract
No abstract availableThis publication has 74 references indexed in Scilit:
- A Win–Win Solution in Oral Delivery of Lipophilic Drugs: Supersaturation via Amorphous Solid Dispersions Increases Apparent Solubility without Sacrifice of Intestinal Membrane PermeabilityMolecular Pharmaceutics, 2012
- Lipid Digestion as a Trigger for Supersaturation: Evaluation of the Impact of Supersaturation Stabilization on the in Vitro and in Vivo Performance of Self-Emulsifying Drug Delivery SystemsMolecular Pharmaceutics, 2012
- Supersaturating Drug Delivery Systems: Fast is Not Necessarily Good EnoughJournal of Pharmaceutical Sciences, 2012
- Precipitation in the small intestine may play a more important role in the in vivo performance of poorly soluble weak bases in the fasted state: Case example nelfinavirEuropean Journal of Pharmaceutics and Biopharmaceutics, 2011
- In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systemsInternational Journal of Pharmaceutics, 2011
- Application of a Biphasic Test for Characterization of In Vitro Drug Release of Immediate Release Formulations of Celecoxib and Its Relevance to In Vivo AbsorptionMolecular Pharmaceutics, 2010
- Analysis of nucleation kinetics of poorly water-soluble drugs in presence of ultrasound and hydroxypropyl methyl cellulose during antisolvent precipitationInternational Journal of Pharmaceutics, 2010
- Enhanced In Vivo Absorption of Itraconazole via Stabilization of Supersaturation Following Acidic-to-Neutral pH TransitionDrug Development and Industrial Pharmacy, 2008
- In vitro and in vivo evaluation of carbamazepine-loaded enteric microparticlesInternational Journal of Pharmaceutics, 2007
- Some hydrodynamic aspects of precipitationPowder Technology, 2001