Precipitation in the small intestine may play a more important role in the in vivo performance of poorly soluble weak bases in the fasted state: Case example nelfinavir
- 31 October 2011
- journal article
- research article
- Published by Elsevier BV in European Journal of Pharmaceutics and Biopharmaceutics
- Vol. 79 (2), 349-356
- https://doi.org/10.1016/j.ejpb.2011.04.005
Abstract
No abstract availableKeywords
This publication has 27 references indexed in Scilit:
- Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predicting Intracolonic Drug SolubilityPharmaceutical Research, 2010
- Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An UpdatePharmaceutical Research, 2008
- Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compoundsEuropean Journal of Pharmaceutics and Biopharmaceutics, 2005
- Assessment of the bioequivalence of two nelfinavir tablet formulations under fed and fasted conditions in healthy subjectsInternational journal of clinical pharmacology and therapeutics, 2005
- The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: a Beagle dog model predicts improved bioavailability and diminished food effect on absorption in humanInternational Journal of Pharmaceutics, 2004
- Drug, Meal and Formulation Interactions Influencing Drug Absorption After Oral AdministrationClinical Pharmacokinetics, 1999
- Effects of Food on Clinical PharmacokineticsClinical Pharmacokinetics, 1999
- Dissolution Testing as a Prognostic Tool for Oral Drug Absorption: Immediate Release Dosage FormsPharmaceutical Research, 1998
- Evaluation of Various Dissolution Media for Predicting In Vivo Performance of Class I and II DrugsPharmaceutical Research, 1998
- Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animalsBiopharmaceutics & Drug Disposition, 1995