Bioaccumulation and Effects of CdTe/CdS Quantum Dots on Chlamydomonas reinhardtii – Nanoparticles or the Free Ions?
- 25 August 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Environmental Science & Technology
- Vol. 45 (18), 7664-7669
- https://doi.org/10.1021/es201193s
Abstract
In order to properly assess the environmental risk of engineered nanoparticles (ENP), it is necessary to determine their fate (including dissolution, aggregation, and bioaccumulation) under representative environmental conditions. CdTe/CdS quantum dots (QD), such as those used in medical imaging, are known to release Cd(2+) due (mainly) to the dissolution of their outer shell. In this study, Chlamydomonas reinhardtii was exposed to either a soluble Cd salt or QD at similar concentrations of total Cd. Free Cd concentrations were measured using the Absence of Gradients and Nernstian Equilibrium Stripping technique. QD dissolution increased with decreasing pH and with increasing QD concentration. When exposed to QD, bioaccumulation was largely accounted for by dissolved Cd. Nonetheless, QD were shown to be taken up by the cells and to provoke unique biological effects. Whole transcriptome screening using RNA-Seq analysis showed that the free Cd and the QD had distinctly different biological effects.Keywords
This publication has 39 references indexed in Scilit:
- Quantum Dot Weathering Results in Microbial ToxicityEnvironmental Science & Technology, 2008
- Aqueous toxicity and food chain transfer of quantum dots™ in freshwater algae and Ceriodaphnia dubiaEnvironmental Toxicology and Chemistry, 2008
- Quantum dot bioconjugates for imaging, labelling and sensingNature Materials, 2005
- Uptake of CdSe and CdSe/ZnS Quantum Dots into Bacteria via Purine-Dependent MechanismsApplied and Environmental Microbiology, 2005
- Quantum Dots for Live Cells, in Vivo Imaging, and DiagnosticsScience, 2005
- Probing the Cytotoxicity of Semiconductor Quantum DotsNano Letters, 2003
- Quantum Dots as Strain- and Metabolism-Specific Microbiological LabelsApplied and Environmental Microbiology, 2003
- Photochemical Instability of CdSe Nanocrystals Coated by Hydrophilic ThiolsJournal of the American Chemical Society, 2001
- Semiconductor Clusters, Nanocrystals, and Quantum DotsScience, 1996
- Perspectives on the Physical Chemistry of Semiconductor NanocrystalsThe Journal of Physical Chemistry, 1996