Regulation of TGF-β signalling by protein phosphatases
- 13 August 2010
- journal article
- review article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 430 (2), 191-198
- https://doi.org/10.1042/bj20100427
Abstract
Tight regulation of TGF-β (transforming growth factor-β) superfamily signalling is important for normal cellular functions and tissue homoeostasis. Since TGF-β superfamily signalling pathways are activated by a short phosphorylation cascade, from receptor phosphorylation to subsequent phosphorylation and activation of downstream signal transducer R-Smads (receptor-activated Smads), reversible phosphorylation serves as a critical step to assure proper TGF-β signalling. The present article will review the current progress on the understanding of dynamic phosphorylation in TGF-β signalling and the essential role of protein phosphatases in this process.This publication has 97 references indexed in Scilit:
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