Mechanism of activation of the TGF-β receptor
- 1 August 1994
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 370 (6488), 341-347
- https://doi.org/10.1038/370341a0
Abstract
Transforming growth factor-beta (TGF-beta) signals by contacting two distantly related transmembrane serine/threonine kinases called receptors I and II. The role of these molecules in signalling has now been determined. TGF-beta binds directly to receptor II, which is a constitutively active kinase. Bound TGF-beta is then recognized by receptor I which is recruited into the complex and becomes phosphorylated by receptor II. Phosphorylation allows receptor I to propagate the signal to downstream substrates. This provides a mechanism by which a cytokine can generate the first step of a signalling cascade.Keywords
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