Custom Cerium Oxide Nanoparticles Protect against a Free Radical Mediated Autoimmune Degenerative Disease in the Brain
- 22 November 2013
- journal article
- Published by American Chemical Society (ACS) in ACS Nano
- Vol. 7 (12), 10582-10596
- https://doi.org/10.1021/nn403743b
Abstract
Cerium oxide nanoparticles are potent antioxidants, based on their ability to either donate or receive electrons as they alternate between the +3 and +4 valence states. The dual oxidation state of ceria has made it an ideal catalyst in industrial applications, and more recently, nanoceria’s efficacy in neutralizing biologically generated free radicals has been explored in biological applications. Here, we report the in vivo characteristics of custom-synthesized cerium oxide nanoparticles (CeNPs) in an animal model of immunological and free-radical mediated oxidative injury leading to neurodegenerative disease. The CeNPs are 2.9 nm in diameter, monodispersed and have a −23.5 mV zeta potential when stabilized with citrate/EDTA. This stabilizer coating resists being ‘washed’ off in physiological salt solutions, and the CeNPs remain monodispersed for long durations in high ionic strength saline. The plasma half-life of the CeNPs is ∼4.0 h, far longer than previously described, stabilized ceria nanoparticles. When administered intravenously to mice, the CeNPs were well tolerated and taken up by the liver and spleen much less than previous nanoceria formulations. The CeNPs were also able to penetrate the brain, reduce reactive oxygen species levels, and alleviate clinical symptoms and motor deficits in mice with a murine model of multiple sclerosis. Thus, CeNPs may be useful in mitigating tissue damage arising from free radical accumulation in biological systems.Keywords
This publication has 76 references indexed in Scilit:
- Ceria Nanoparticles that can Protect against Ischemic StrokeAngewandte Chemie-International Edition, 2012
- Biomedical Applications of Metal Oxide NanoparticlesPublished by Springer Science and Business Media LLC ,2011
- Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathwaysNeurobiology of Disease, 2011
- Cerium Oxide Nanoparticles for the Treatment of Neurological Oxidative Stress DiseasesACS Symposium Series, 2011
- Response of nanoparticle structure to different types of surface environments: Wide-angle x-ray scattering and molecular dynamics simulationsPhysical Review B, 2010
- Protection from radiation-induced pneumonitis using cerium oxide nanoparticlesNanomedicine: Nanotechnology, Biology and Medicine, 2009
- Cerium and yttrium oxide nanoparticles are neuroprotectiveBiochemical and Biophysical Research Communications, 2006
- Vacancy Engineered Ceria Nanostructures for Protection from Radiation-Induced Cellular DamageNano Letters, 2005
- Oxygen Vacancies and Catalysis on Ceria SurfacesScience, 2005
- Structural and Oxygen Storage/Release Properties of CeO2-Based Solid SolutionsComments on Inorganic Chemistry, 1999