Ceria Nanoparticles that can Protect against Ischemic Stroke
- 11 September 2012
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 51 (44), 11039-11043
- https://doi.org/10.1002/anie.201203780
Abstract
Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.Keywords
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