Metallic mesh-based terahertz biosensing of single- and double-stranded DNA
- 1 November 2012
- journal article
- research article
- Published by AIP Publishing in Journal of Applied Physics
- Vol. 112 (9), 094702
- https://doi.org/10.1063/1.4761966
Abstract
We report on a promising approach for the label-free analysis of DNA molecules with electromagnetic surface waves in the terahertz (THz) region. A metallic mesh with a polyvinylidene difluoride membrane is employed for THz transmission analysis. The metallic mesh with opening holes provides a sharp dip structure in a THz transmission spectrum, which is sensitive to a small change of the refractive index of a sample on the metallic mesh surface. The optical properties of a small amount of DNA molecules cannot be investigated by a free-space THz measurement because of the low absorption coefficients of such samples. However, metallic mesh-based THz measurement revealed the difference in optical properties between single- and double-stranded DNA molecules on the basis of refractive index, as estimated from a dip frequency shift of the metallic mesh. Therefore, our metallic-based THz technique provides a dramatically enhanced sensitivity, and demonstrates the potential of our approach of the analysis of biologically relevant DNA samples.Keywords
This publication has 15 references indexed in Scilit:
- Analysis of Sharp Dip Structures on Terahertz Transmission Spectra of Metallic MeshesJapanese Journal of Applied Physics, 2012
- Label-free THz sensing of living body-related molecular binding using a metallic meshBiochemical and Biophysical Research Communications, 2011
- Terahertz sensing method for protein detection using a thin metallic meshApplied Physics Letters, 2007
- Effect of a thin dielectric layer on terahertz transmission characteristics for metal hole arraysOptics Letters, 2005
- Integrated THz technology for label-free genetic diagnosticsApplied Physics Letters, 2002
- Expression profiling using cDNA microarraysNature Genetics, 1999
- High density synthetic oligonucleotide arraysNature Genetics, 1999
- Metallic mesh properties and design of submillimeter filtersInternational Journal of Infrared and Millimeter Waves, 1981
- Transmission of Microwave Through Perforated Flat Plates of Finite ThicknessIEEE Transactions on Microwave Theory and Techniques, 1973
- Tunable Submillimeter Interferometers of the Fabry-Perot TypeIEEE Transactions on Microwave Theory and Techniques, 1963