Integrated THz technology for label-free genetic diagnostics
- 7 January 2002
- journal article
- Published by AIP Publishing in Applied Physics Letters
- Vol. 80 (1), 154-156
- https://doi.org/10.1063/1.1428619
Abstract
We report on a promising approach for the label-free analysis of DNA molecules using direct probing of the binding state of DNA with electromagnetic waves at THz frequencies. Passive THz resonator devices based on planar waveguides are used as sample carriers and transducers for THz transmission analysis. In comparison to a formerly used free-space detection scheme, this method provides a drastically enhanced sensitivity enabling analysis down to femtomol levels. We examine the potential of our approach on biologically relevant DNA samples and demonstrate the detection of single base mutations on DNA molecules.Keywords
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