Cytologic diagnosis of pulmonary adenocarcinoma with micropapillary pattern: Does it correlate with the histologic findings?
- 3 February 2009
- journal article
- Published by Wiley in Diagnostic Cytopathology
- Vol. 37 (5), 333-339
- https://doi.org/10.1002/dc.21011
Abstract
Micropapillary adenocarcinoma is associated with poor‐prognosis in several organs including the lung. The presence of small tight balls of neoplastic cells devoid of fibrovascular core in cytological preparations (micropapillary tufts) has been described as characteristic of micropapillary adenocarcinoma. In the lung, however, this criterion has not been validated. The cytological material of 46 cases of histologically proven pulmonary adenocarcinoma with a micropapillary component was compared to 33 cases with no micropapillary component to determine the specificity of micropapillary tufts for the histologic diagnosis of micropapillary adenocarcinoma. Other histologic patterns of invasive pulmonary adenocarcinomas (acinar, papillary, and solid) were also compared with patterns of neoplastic cell aggregates in cytological preparations. There were no significant differences in the distribution of micropapillary clusters between the two groups. The positive predictive value for the cytologic diagnosis of a micropapillary component in lung adenocarcinomas was of 64%. Similar findings were observed for other invasive patterns. Therefore, the detection of micropapillary tufts in cytology is not specific for the diagnosis of a pulmonary micropapillary adenocarcinoma in the lung. Diagn. Cytopathol. 2009.Keywords
This publication has 35 references indexed in Scilit:
- Aggressive invasive micropapillary salivary duct carcinoma of the parotid glandPathology International, 2008
- Reliability of cytologic diagnosis of early lung cancerCancer, 2007
- A micropapillary pattern is predictive of a poor prognosis in lung adenocarcinoma, and reduced surfactant apoprotein A expression in the micropapillary pattern is an excellent indicator of a poor prognosisLaboratory Investigation, 2007
- Micropapillary pattern and grade of stromal invasion in pT1 adenocarcinoma of the lung: usefulness as prognostic factorsLaboratory Investigation, 2007
- Fine Needle Aspiration Cytologic Findings of Micropapillary Carcinoma in the LungActa Cytologica, 2007
- Lung adenocarcinoma with a micropapillary pattern: a clinicopathological study of 25 casesAPMIS, 2006
- Intracytoplasmic lumina in invasive micropapillary carcinoma of the lungDiagnostic Cytopathology, 2006
- Cytopathologic Diagnosis of Bronchioloalveolar CarcinomaAmerican Journal of Clinical Pathology, 2004
- Micropapillary clusters in early-stage lung adenocarcinomasCancer, 2004