Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland
- 1 May 2008
- journal article
- case report
- Published by Wiley in Pathology International
- Vol. 58 (5), 322-326
- https://doi.org/10.1111/j.1440-1827.2008.02231.x
Abstract
The presence of invasive micropapillary component has been reported to be associated with salivary duct carcinoma and poor outcomes. Herein is described a rare case of invasive micropapillary salivary duct carcinoma of the parotid gland in a 60-year-old man. The micropapillary component was approximately 70% of the area of the tumor. Squamous differentiation was focally seen adjacent to the micropapillary component. On immunohistochemistry the ordinary salivary duct carcinoma component was positive for gross cystic disease fluid protein-15 (GCDFP-15), androgen receptor (AR), and HER2/neu, whereas both micropapillary and squamous components were negative for GCDFP-15 and AR. Immunohistochemical staining for D2-40 highlighted the lymph vessel invasion of tumor cells. This patient developed metastases in the lymph nodes of the neck, and also in the liver, lung, and brain. The lymph nodes and liver metastases had both ordinary salivary duct carcinoma and micropapillary components. The patient died of tumor 11 months after the initial surgical operation. The results support that the presence of micropapillary component is associated with more aggressive behavior of salivary duct carcinoma. It is also important for pathologists to recognize that GCDFP-15 and AR expression can be reduced in micropapillary carcinoma in the differential diagnosis of metastatic tumor.Keywords
This publication has 12 references indexed in Scilit:
- Invasive colorectal micropapillary carcinoma: an aggressive variant of adenocarcinomaHuman Pathology, 2006
- Clinical and immunohistologic typing of salivary duct carcinomaCancer, 2005
- Micropapillary variant of urothelial carcinoma of the urinary bladder; a clinicopathological and immunohistochemical studyHistopathology, 2004
- Invasive Micropapillary Salivary Duct CarcinomaThe American Journal of Surgical Pathology, 2004
- Serous Borderline Tumors of the OvaryThe American Journal of Surgical Pathology, 2002
- Micropapillary Component in Lung AdenocarcinomaThe American Journal of Surgical Pathology, 2002
- Clinicopathologic Analysis of Invasive Micropapillary Differentiation in Breast CarcinomaLaboratory Investigation, 2001
- Prognostic significance of biomarkers (c-erbB-2, p53, proliferating cell nuclear antigen, and DNA content) in salivary duct carcinomaHuman Pathology, 1996
- Micropapillary Variant of Transitional Cell Carcinoma of the Urinary Bladder Histologic Pattern Resembling Ovarian Papillary Serous CarcinomaThe American Journal of Surgical Pathology, 1994
- Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian CancerScience, 1989