Occult and previous hepatitis B virus infection are not associated with hepatocellular carcinoma in United States patients with chronic hepatitis C
Open Access
- 3 March 2011
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hepatology
- Vol. 54 (2), 434-442
- https://doi.org/10.1002/hep.24257
Abstract
Previous studies have suggested that prior exposure to hepatitis B virus (HBV) infection may increase the risk of development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C. The aim of this study was to compare the prevalence of previous or occult HBV infection in a cohort of hepatitis B surface antigen–negative patients with histologically advanced chronic hepatitis C in the United States who did or did not develop HCC. Stored sera from 91 patients with HCC and 182 matched controls who participated in the Hepatitis C Antiviral Long‐term Treatment against Cirrhosis (HALT‐C) Trial were tested for hepatitis B core antibody (anti‐HBc), hepatitis B surface antibody, and HBV DNA. Frozen liver samples from 28 HCC cases and 55 controls were tested for HBV DNA by way of real‐time polymerase chain reaction. Anti‐HBc (as a marker of previous HBV infection) was present in the serum of 41.8% HCC cases and 45.6% controls (P= 0.54); anti‐HBc alone was present in 16.5% of HCC cases and 24.7% of controls. HBV DNA was detected in the serum of only one control subject and no patients with HCC. HBV DNA (as a marker of occult HBV infection) was detected in the livers of 10.7% of HCC cases and 23.6% of controls (P = 0.18). Conclusion: Although almost half the patients in the HALT‐C Trial had serological evidence of previous HBV infection, there was no difference in prevalence of anti‐HBc in serum or HBV DNA in liver between patients who did or did not develop HCC. In the United States, neither previous nor occult HBV infection is an important factor in HCC development among patients with advanced chronic hepatitis C. (Hepatology 2011;)This publication has 33 references indexed in Scilit:
- Erratum: Prevalence and significance of occult hepatitis B in a liver transplant population with chronic hepatitis CLiver Transplantation, 2011
- Prolonged Therapy of Advanced Chronic Hepatitis C with Low-Dose PeginterferonThe New England Journal of Medicine, 2008
- The Characteristics of the Cell-Mediated Immune Response Identify Different Profiles of Occult Hepatitis B Virus InfectionGastroenterology, 2008
- Occult hepatitis B virus infection as a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C in whom viral eradication failsHepatology Research, 2008
- Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients with Hepatitis C Virus-Related Chronic Liver DiseaseIntervirology, 2008
- Prevalence and significance of occult hepatitis B in a liver transplant population with chronic hepatitis CLiver Transplantation, 2008
- Impact of occult hepatitis B virus infection and prior hepatitis B virus infection on development of hepatocellular carcinoma in patients with liver cirrhosis due to hepatitis C virusScandinavian Journal of Gastroenterology, 2008
- Prevalence of Low-Level Hepatitis B Viremia in Patients with HBV Surface Antigen-Negative Hepatocellular Carcinoma with and without Hepatitis C Virus Infection in Japan: Analysis by COBAS TaqMan Real-Time PCRIntervirology, 2007
- HBsAg‐negative hepatitis B virus infections in hepatitis C virus‐associated hepatocellular carcinomaJournal of Viral Hepatitis, 2005
- Survey of Hepatitis B Virus Co-infection in Hepatitis C Virus-infected Patients Suffering from Chronic Hepatitis and Hepatocellular Carcinoma in JapanJapanese Journal of Cancer Research, 1999