Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients with Hepatitis C Virus-Related Chronic Liver Disease
- 18 March 2008
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 51 (1), 59-68
- https://doi.org/10.1159/000121363
Abstract
Aims: To prospectively study whether occult hepatitis B virus (HBV) infection can promote the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-related chronic liver disease. In addition, to evaluate the difference among HBV DNA-negative patients and patients with high and low HBV copy numbers. Methods: A total of 167 patients with HCV-related chronic liver disease without HBV surface antigen (HBsAg) were studied. HBV DNA in liver tissue was determined using polymerase chain reaction (PCR). Results: HBV DNA was detected in 9 of 167 patients (5.4%) by single PCR and in 25 patients (15.0%) by nested PCR. HCC developed in 12 of 167 patients (7.2%). Ten of 142 HBV DNA-negative patients (7.0%) and 2 of 9 patients with a high HBV copy number (22.2%) developed HCC, whereas none of 16 patients with a low HBV copy number developed HCC. The incidence rate of HCC in patients with a high HBV copy number was significantly higher than in HBV DNA-negative patients and patients with low HBV copy number. Conclusion: A high amount of HBV DNA in liver tissue of HBsAg-negative patients with HCV-related liver disease might be associated with HCC development.Keywords
This publication has 54 references indexed in Scilit:
- A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in JapanThe Esophagus, 2007
- Prevalence of Low-Level Hepatitis B Viremia in Patients with HBV Surface Antigen-Negative Hepatocellular Carcinoma with and without Hepatitis C Virus Infection in Japan: Analysis by COBAS TaqMan Real-Time PCRIntervirology, 2007
- An algorithm for the grading of activity in chronic hepatitis CHepatology, 1996
- HCV-associated liver cancer without cirrhosisThe Lancet, 1995
- Clearance of HBsAg in seven patients with chronic hepatitis BHepatology, 1992
- Hepatocellular carcinomaDigestive Diseases and Sciences, 1991
- Serologic Diagnosis of Acute and Chronic Viral HepatitisSeminars in Liver Disease, 1991
- Hepatitis B Virus DNA in Patients with Chronic Liver Disease and Negative Tests for Hepatitis B Surface AntigenNew England Journal of Medicine, 1985
- Type B Hepatitis after Transfusion with Blood Containing Antibody to Hepatitis B Core AntigenNew England Journal of Medicine, 1978