Disruption of the Plasmodium falciparum PfPMT Gene Results in a Complete Loss of Phosphatidylcholine Biosynthesis via the Serine-Decarboxylase-Phosphoethanolamine-Methyltransferase Pathway and Severe Growth and Survival Defects
Open Access
- 1 October 2008
- journal article
- Published by Elsevier BV
- Vol. 283 (41), 27636-27643
- https://doi.org/10.1074/jbc.m804360200
Abstract
No abstract availableThis publication has 30 references indexed in Scilit:
- Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopyMolecular and Biochemical Parasitology, 2008
- Choline Induces Transcriptional Repression and Proteasomal Degradation of the Malarial Phosphoethanolamine MethyltransferaseEukaryotic Cell, 2007
- PhosphoethanolamineN-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis inCaenorhabditis elegansBiochemical Journal, 2007
- Spinning Disk Confocal Microscopy of Live, Intraerythrocytic Malarial Parasites. 1. Quantification of Hemozoin Development for Drug Sensitive versus Resistant MalariaBiochemistry, 2006
- Localization of the Phosphoethanolamine Methyltransferase of the Human Malaria Parasite Plasmodium falciparum to the Golgi ApparatusPublished by Elsevier BV ,2006
- The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparumProceedings of the National Academy of Sciences of the United States of America, 2006
- Defining the Role of Phosphomethylethanolamine N-Methyltransferase from Caenorhabditis elegans in Phosphocholine Biosynthesis by Biochemical and Kinetic AnalysisBiochemistry, 2006
- The Isolation and Characterization in Yeast of a Gene for Arabidopsis S-Adenosylmethionine:Phospho-EthanolamineN-MethyltransferasePlant Physiology, 2000
- Phosphoethanolamine Bases as Intermediates in Phosphatidylcholine Synthesis by LemnaPlant Physiology, 1986
- Human Malaria Parasites in Continuous CultureScience, 1976