Perylene-3-ylmethanol: Fluorescent Organic Nanoparticles as a Single-Component Photoresponsive Nanocarrier with Real-Time Monitoring of Anticancer Drug Release
- 24 April 2012
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 134 (18), 7656-7659
- https://doi.org/10.1021/ja302482k
Abstract
We report for the first time the use of perylene-3-ylmethanol fluorescent organic nanoparticles as a drug delivery system. In the present system, perylene-3-ylmethanol nanoparticles performed four important roles: (i) “nanocarriers” for drug delivery; (ii) “phototriggers” for the drug release; (iii) fluorescent chromophores for cell imaging; and (iv) detectors for real time-monitoring of drug release. In vitro biological studies revealed that the newly developed perylene-3-ylmethanol nanoparticles exhibit good biocompatibility and cellular uptake as well as efficient photoregulated anticancer drug release ability. Such fluorescent organic nanoparticles may open up new perspectives for designing a new class of promising photoresponsive nanocarriers for drug delivery.Keywords
This publication has 25 references indexed in Scilit:
- Synthesis of triazolo-thiadiazole fluorescent organic nanoparticles as primary sensor toward Ag+ and the complex of Ag+ as secondary sensor toward cysteineSensors and Actuators B: Chemical, 2011
- Gold nanocages covered by smart polymers for controlled release with near-infrared lightNature Materials, 2009
- Dual-Controlled Nanoparticles Exhibiting AND LogicJournal of the American Chemical Society, 2009
- A New Two‐Photon‐Sensitive Block Copolymer NanocarrierAngewandte Chemie-International Edition, 2009
- Photoregulated Release of Caged Anticancer Drugs from Gold NanoparticlesJournal of the American Chemical Society, 2009
- Photoinduced Intracellular Controlled Release Drug Delivery in Human Cells by Gold-Capped Mesoporous Silica NanosphereJournal of the American Chemical Society, 2009
- Photoinduced Release of Guest Molecules by Supramolecular Transformation of Self‐Assembled Aggregates Derived from DendronsAngewandte Chemie-International Edition, 2008
- Installing Dynamic Molecular Photomechanics in Mesopores: A Multifunctional Controlled‐Release NanosystemAngewandte Chemie-International Edition, 2007
- The size-dependent optical properties of pyrazoline nanoparticlesMolecular Crystals and Liquid Crystals, 2004
- Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silicaNature, 2003