Vitamin D Deficiency, Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis
- 1 January 2012
- journal article
- research article
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 33 (5), 297-305
- https://doi.org/10.1159/000339702
Abstract
Background: Recent preventive strategies for patients with cognitive impairment include the identification of modifiable somatic risk factors like vitamin D deficiency. Methods: A systematic literature research and meta-analysis were conducted to assess the association of cognitive impairment and vitamin D deficiency. Results: Data from cross-sectional and longitudinal studies suggest an association between cognitive impairment and vitamin D deficiency. Meta-analysis of 5 cross-sectional and 2 longitudinal studies comprising 7,688 participants showed an increased risk of cognitive impairment in those with low vitamin D compared with normal vitamin D (OR 2.39, 95% CI 1.91–3.00; p < 0.0001). Conclusions: Methodological limitations of these studies comprise heterogeneity of study populations, different forms of cognitive assessment, the problem of reverse causality, different definitions of vitamin D deficiency and inconsistent control for confounders. As the value of vitamin D substitution in cognitive impairment remains doubtful, a long-time major placebo-controlled randomized trial of vitamin D supplementation in participants with mild cognitive impairment (MCI) should be started.Keywords
This publication has 36 references indexed in Scilit:
- The projected effect of risk factor reduction on Alzheimer's disease prevalenceThe Lancet Neurology, 2011
- Vitamin D, Cognitive Dysfunction and Dementia in Older AdultsCNS Drugs, 2011
- Vitamin D and Cognitive Impairment in the Elderly U.S. PopulationThe Journals of Gerontology: Series A, 2010
- Vitamin D status and measures of cognitive function in healthy older European adultsEuropean Journal of Clinical Nutrition, 2010
- 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly menNeurology, 2010
- 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home servicesNeurology, 2010
- Vitamin D Is Associated With Cognitive Function in Elders Receiving Home Health ServicesThe Journals of Gerontology: Series A, 2009
- Serum 25-Hydroxyvitamin D Concentration and Cognitive ImpairmentJournal of Geriatric Psychiatry and Neurology, 2008
- Estimates of optimal vitamin D statusOsteoporosis International, 2005
- Distribution of the Vitamin D receptor and 1α-hydroxylase in human brainJournal of Chemical Neuroanatomy, 2005