25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men
- 5 January 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 74 (1), 33-41
- https://doi.org/10.1212/wnl.0b013e3181c7197b
Abstract
Objective: To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline. Methods: We measured 25(OH)D and assessed cognitive function using the Modified Mini-Mental State Examination (3MS) and Trail Making Test Part B (Trails B) in a cohort of 1,604 men enrolled in the Osteoporotic Fractures in Men Study and followed them for an average of 4.6 years for changes in cognitive function. Results: In a model adjusted for age, season, and site, men with lower 25(OH)D levels seemed to have a higher odds of cognitive impairment, but the test for trend did not reach significance (impairment by 3MS: odds ratio [OR] 1.84, 95% confidence interval [CI] 0.81–4.19 for quartile [Q] 1; 1.41, 0.61–3.28 for Q2; and 1.18, 0.50–2.81 for Q3, compared with Q4 [referent group; p trend = 0.12]; and impairment by Trails B: OR 1.66, 95% CI 0.98–2.82 for Q1; 0.96, 0.54–1.69 for Q2; and 1.30, 0.76–2.22 for Q3, compared with Q4 [p trend = 0.12]). Adjustment for age and education further attenuated the relationships. There was a trend for an independent association between lower 25(OH)D levels and odds of cognitive decline by 3MS performance (multivariable OR 1.41, 95% CI 0.89–2.23 for Q1; 1.28, 0.84–1.95 for Q2; and 1.06, 0.70–1.62 for Q3, compared with Q4 [p = 0.10]), but no association with cognitive decline by Trails B. Conclusion: We found little evidence of independent associations between lower 25-hydroxyvitamin D level and baseline global and executive cognitive function or incident cognitive decline.Keywords
This publication has 39 references indexed in Scilit:
- Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European menJournal of Neurology, Neurosurgery & Psychiatry, 2009
- Vitamin D Is Associated With Cognitive Function in Elders Receiving Home Health ServicesThe Journals of Gerontology: Series A, 2009
- Vitamin D Deficiency Is Associated With Worse Cognitive Performance and Lower Bone Density in Older African AmericansJournal of the National Medical Association, 2009
- Vitamin D and Cancer Incidence in the Harvard CohortsAnnals of Epidemiology, 2009
- Increased anxiety in mice lacking vitamin D receptor geneNeuroReport, 2004
- Vitamin D3—implications for brain developmentThe Journal of Steroid Biochemistry and Molecular Biology, 2004
- Vitamin d3 and brain developmentNeuroscience, 2003
- Protective effects of 1α,25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic cultureNeuropharmacology, 2001
- Vitamin D Hormone Confers Neuroprotection in Parallel with Downregulation of L-Type Calcium Channel Expression in Hippocampal NeuronsJournal of Neuroscience, 2001
- Rat oligodendrocytes express the vitamin D3 receptor and respond to 1,25-dihydroxyvitamin D3Glia, 2000