New tools for functional mammalian cancer genetics
- 1 December 2003
- journal article
- innovation
- Published by Springer Science and Business Media LLC in Nature Reviews Cancer
- Vol. 3 (10), 781-789
- https://doi.org/10.1038/nrc1191
Abstract
Knowledge of the function of individual genes that encode components of cell-signalling pathways is crucial to our understanding of normal growth control and its deregulation in cancer, but we have functional information for only ∼ 15% of human genes at present. Several new technologies have recently become available to identify gene function in mammalian cells using high-throughput genetic screens. These new tools will make it possible to identify new and innovative classes of anticancer drugs, including those that show synthetic lethal interactions with cancer-specific mutations.Keywords
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