Single molecule analysis by surfaced-enhanced Raman scattering
Top Cited Papers
- 27 February 2008
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 37 (5), 946-954
- https://doi.org/10.1039/b709739p
Abstract
Our main objective in this tutorial review is to provide insight into some of the questions surrounding single molecule detection (SMD) using surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS). Discovered thirty years ago, SERS is now a powerful analytical tool, strongly tied to plasmonics, a field that encompasses and profits from the optical enhancement found in nanostructures that support localized plasmon excitations. The spectrum of the single molecule carries the quantum fingerprints of the system modulated by the molecule–nanostructure interactions and the electronic resonances that may result under laser excitation. This information is embedded in vibrational band parameters. The dynamics and the molecular environment will affect the bandwidth of the observed Raman bands. In addition, the localized surface plasmon resonances (LSPR) empower the nanostructure with a number of optical properties that will also leave their mark on the observed inelastic scattering process. Therefore, controlling size, shape and the formation of the aggregation state (or fractality) of certain metallic nanostructures becomes a main task for experimental SERS/SERRS. This molecule–nanostructure coupling may, inevitably, lead to spectral fluctuations, increase photobleaching or photochemistry. An attempt is made here to guide the interpretation of this wealth of information when approaching the single molecule regime.Keywords
This publication has 40 references indexed in Scilit:
- Surface Enhanced Raman Scattering Enhancement Factors: A Comprehensive StudyThe Journal of Physical Chemistry C, 2007
- Chemically Patterned Microspheres for Controlled Nanoparticle Assembly in the Construction of SERS Hot SpotsJournal of the American Chemical Society, 2007
- On the significance of Shalaev's ‘hot spots’ in ensemble and single-molecule SERS by adsorbates on metallic films at the percolation thresholdJournal of Raman Spectroscopy, 2006
- Why gold nanoparticles are more precious than pretty gold: Noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapesChemical Society Reviews, 2005
- Progress in plasmonic engineering of surface-enhanced Raman-scattering substrates toward ultra-trace analysisAnalytical and Bioanalytical Chemistry, 2005
- A Dozen Years of Single-Molecule Spectroscopy in Physics, Chemistry, and BiophysicsThe Journal of Physical Chemistry B, 2002
- Light-Scattering Submicroscopic Particles as Highly Fluorescent Analogs and Their Use as Tracer Labels in Clinical and Biological ApplicationsAnalytical Biochemistry, 1998
- Mode localization in self-affine fractal interfaces observed by near-field microscopyPhysical Review B, 1998
- Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)Physical Review Letters, 1997
- Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman ScatteringScience, 1997