Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering
- 21 February 1997
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 275 (5303), 1102-1106
- https://doi.org/10.1126/science.275.5303.1102
Abstract
Optical detection and spectroscopy of single molecules and single nanoparticles have been achieved at room temperature with the use of surface-enhanced Raman scattering. Individual silver colloidal nanoparticles were screened from a large heterogeneous population for special size-dependent properties and were then used to amplify the spectroscopic signatures of adsorbed molecules. For single rhodamine 6G molecules adsorbed on the selected nanoparticles, the intrinsic Raman enhancement factors were on the order of 10 14 to 10 15 , much larger than the ensemble-averaged values derived from conventional measurements. This enormous enhancement leads to vibrational Raman signals that are more intense and more stable than single-molecule fluorescence.Keywords
This publication has 37 references indexed in Scilit:
- Probing the interaction between two single molecules: fluorescence resonance energy transfer between a single donor and a single acceptor.Proceedings of the National Academy of Sciences of the United States of America, 1996
- Imaging and Time-Resolved Spectroscopy of Single Molecules at an InterfaceScience, 1996
- Semiconductor Clusters, Nanocrystals, and Quantum DotsScience, 1996
- Vibronic Spectroscopy of Individual Molecules in SolidsThe Journal of Physical Chemistry, 1994
- Examining Nanoenvironments in Solids on the Scale of a Single, Isolated Impurity MoleculeScience, 1994
- Near-field spectroscopy of single molecules at room temperatureNature, 1994
- A nanometer-scale galvanic cellThe Journal of Physical Chemistry, 1992
- Surface-enhanced Raman scatteringJournal of Physics: Condensed Matter, 1992
- Surface-enhanced spectroscopyReviews of Modern Physics, 1985
- Surface-enhanced resonance Raman spectroscopy of Rhodamine 6G adsorbed on colloidal silverThe Journal of Physical Chemistry, 1984